Exploring PTDH-P450BM3 Variants for the Synthesis of Drug Metabolites-Reference-Cited by-同舟云学术

Exploring PTDH-P450BM3 Variants for the Synthesis of Drug Metabolites

Published:2018-01-17 Issue:4 Volume:19 Page:326-337
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Beyer Nina¹,Kulig Justyna K.²³,Fraaije Marco W.¹,Hayes Martin A.²,Janssen Dick B.¹

Affiliation:

1. Biotransformation and Biocatalysis; University of Groningen; Nijenborgh 4 9747AG Groningen The Netherlands

2. Cardiovascular and Metabolic Diseases; DMPK; Innovative Medicines and Early Development; AstraZeneca R&D Gothenburg; Pepparedsleden 1 43150 Mölndal Sweden

3. Crop Science Division; Bayer AG; Alfred-Nobel-Strasse 50 40789 Monheim am Rhein Germany

Funder

FP7 People: Marie-Curie Actions

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cbic.201700470/fullpdf

Reference84 articles.

1. The role of the liver in drug metabolism

2. Preclinical Pharmacokinetics: An Approach Towards Safer and Efficacious Drugs

3. Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites

4. Metabolites in safety testing

5. Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions

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