Active-Site-Directed Inhibitors of Prolyl Oligopeptidase Abolish Its Conformational Dynamics

Author:

López Abraham12,Herranz-Trillo Fátima3,Kotev Martin4,Gairí Margarida5,Guallar Víctor46,Bernadó Pau3,Millet Oscar7,Tarragó Teresa18,Giralt Ernest12

Affiliation:

1. Chemistry and Molecular Pharmacology Program; Institute for Research in Biomedicine; The Barcelona Institute of Science and Technology; Baldiri Reixac 10 08028 Barcelona Spain

2. Department of Organic Chemistry; University of Barcelona; Martí i Franquès, 1-11 08028 Barcelona Spain

3. Centre de Biochimie Structurale; INSERM U1054; CNRS UMR 5048; Université de Montpellier 1 and 2; 29 rue de Navacelles 34090 Montpellier France

4. Joint BSC-CRG-IRB Research Program in Computational Biology; Barcelona Supercomputing Center; Jordi Girona 31 08034 Barcelona Spain

5. NMR Facility; Scientific and Technological Centers University of Barcelona (CCiTUB); Baldiri Reixac 10 08028 Barcelona Spain

6. Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23; 08010 Barcelona Spain

7. Structural Biology Unit; CIC bioGUNE; Parque Tecnológico de Vizcaya, Ed. 800 48160 Derio Spain

8. Iproteos; S L; Barcelona Science Park; Baldiri Reixac 10 08028 Barcelona Spain

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

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