One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites-Reference-Cited by-同舟云学术

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One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites

Published:2015-06-15 Issue:11 Volume:16 Page:1560-1564
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Fischer Marcus¹,Shoichet Brian K.¹,Fraser James S.²

Affiliation:

1. Department of Pharmaceutical Chemistry, University of California San Francisco, 1700 4th St., Byers Hall, BH‐501, Box 2550, San Francisco, CA 94158 (USA)

2. Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, 600 16th St., Genentech Hall, S472E, Box 2240, San Francisco, CA 94158 (USA)

Funder

Funded Access

NIH

NSF

U.S. Department of Energy

Program Breakthrough Biomedical Research

Sandler Foundation

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.201500196

Reference30 articles.

1. Fragment-based ligand discovery

2. Discovering High-Affinity Ligands for Proteins

3.

4. Experiences in fragment-based drug discovery

5. Navigating chemical space for biology and medicine

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3. Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals;Acta Crystallographica Section D Structural Biology;2024-07-25

4. Differential responses in the core, active site and peripheral regions of cytochrome c peroxidase to extreme pressure and temperature;2024-07-25

5. Fast Quantitative Validation of 3D Models of Low-Affinity Protein–Ligand Complexes by STD NMR Spectroscopy;Journal of Medicinal Chemistry;2024-06-07

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