Hyperthermic isolated perfusion with melphalan in the treatment of advanced malignant melanoma of the lower limb

Author:

Skene A I1,Bulman A S2,Williams T R2,Thomas J Meirion2,Westbury G1

Affiliation:

1. Department of Academic Surgery, The Royal Marsden Hospital, Fulham Road, London, UK

2. Westminster Hospital, Dean Ryle Street, London SW1P 2AP, UK

Abstract

Abstract A retrospective study of 91 patients with malignant melanoma treated by lower limb isolated hyperthermic regional perfusion was performed. Objective response in patients with evaluable disease was 78 per cent. The role of perfusion as primary treatment of large melanomas of the foot is confirmed and recommended. Control of locoregional disease and limb salvage remains a valuable and attainable therapeutic goal using this technique.

Publisher

Oxford University Press (OUP)

Subject

Surgery

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2. Hyperthermic perfusion of recurrent malignant melanoma of the extremity;Hafstrom;Acta Chir Scand,1980

3. Hyperthermic perfusion with chemotherapy for cancers of the extremities;Stehlin;Surg Gynecol Obstet,1969

4. The use of regional chemotherapy in the management of malignant melanoma;Krementz;World J Surg,1979

5. A prospective randomised study of regional extremity perfusion in patients with malignant melanoma;Ghussen;Ann Surg,1984

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