Reticuloendothelial failure in chronic intra-abdominal sepsis: The role of opsonic fibronectin

Author:

Cheslyn-Curtis S1,Aldridge M C1,Dudley H A F1

Affiliation:

1. Academic Surgical Unit, Queen Elizabeth The Queen Mother Wing, St. Mary's Hospital, London W2 1NY, UK

Abstract

Abstract Severe sepsis leads to depression of the reticuloendothelial (RE) system with delayed bloodstream clearance of particulate matter and bacteria. Fibronectin may be an important opsonin of the RE system and low fibronectin levels often accompany severe sepsis in man. We have investigated the effect of prolonged intra-abdominal sepsis on plasma fibronectin concentrations and RE function. Serial plasma fibronectin concentrations were determined in rabbits for 2 weeks after either the induction of sepsis (appendix abscess) (n = 6) or laparotomy only (n = 6). RE function was measured at 2 weeks by determining the clearance kinetics and organ distribution of low dose technetium tin colloid (TTC). There was an early transient depression in plasma fibronectin values followed by elevated concentrations at 48–72 h which were more marked in the sepsis group. There was a delay in the blood clearance with reduced hepatic and increased bone uptake of TTC. We conclude that depletion of opsonic fibronectin is unlikely to be an important factor contributing to the impairment of RE function associated with intra-abdominal sepsis and that RE depression in septic animals is due to intrinsic Kupffer cell dysfunction.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference21 articles.

1. Purified fibronectin administration to patients with severe abdominal infections. A controlled clinical trial;Lundsgaard-Hansen;Ann Surg,1985

2. The influence of elevated fibronectin levels during sepsis on the distribution of blood-borne particles;Aukburg;Advances in Shock Research,1981

3. Plasma fibronectin concentration in animal models of sepsis and endotoxemia;Grossman;J Surg Res,1983

4. Effect of splenectomy on Gram-negative bacterial clearance in the presence and absence of sepsis;Cheslyn-Curtis;Br J Surg,1988

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3