Intraperitoneal antiseptics in experimental bacterial peritonitis-Reference-Cited by-同舟云学术

Intraperitoneal antiseptics in experimental bacterial peritonitis

Published:1984-08 Issue:8 Volume:71 Page:626-628
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Platt J¹,Jones R A¹,Bucknall R A¹

Affiliation:

1. Imperial Chemical Industries PLC, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

Abstract

Abstract A model of bacterial peritonitis, using mice infected with Escherichia coli, has been used to assess the protective effects of intraperitoneal treatment with antiseptics. Of the five antiseptics tested, only chlorhexidine gluconate had any protective effect, concentrations of 0.05 and 0.02 per cent reducing the mortality to 14 and 50 per cent respectively. The other antiseptics, taurolin, noxytiolin, povidone iodine and hypochlorite were all ineffective. Delayed treatment with chlorhexidine was not as effective as instillation immediately postinfection.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

http://academic.oup.com/bjs/article-pdf/71/8/626/36930662/bjs1800710822.pdf

Reference17 articles.

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4. The efficacy and toxicity study of chlorhexidine in combination with peritoneal lavage in experimental E. coli peritonitis;Kanzaki;Journal of the Tokyo Women's Medical College (Japan),1981

5. Essais cliniques d'un nouvel antiseptique: la chlorhexidine;Gille;Médécine Practicienne,1976

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