Effect of terminal ileal transposition on intestinal absorption following proctocolectomy

Author:

Hotokezaka M1,Nakahara S1,Iwamoto T1,Chijiiwa K1,Mibu R1

Affiliation:

1. Department of Surgery 1, Kyushu University, Faculty of Medicine, Maidashi 3–1–1, Fukuoka 812, Japan

Abstract

Abstract A terminal ileal transposition procedure, in which a distal jejunal segment is interposed between the terminal ileum and the anus following proctocolectomy, is described. Adult mongrel dogs had either terminal ileal transposition (n = 5) or ileoanal anastomosis (n = 6) following two-stage proctocolectomy. Untreated dogs were used as controls (n = 7). Twelve weeks after the second-stage operation, a perfusion study was performed. After terminal ileal transposition the transposed terminal ileum showed a high absorptive capability for sodium, chloride and bile acids (P < 0·05, P < 0·05 and P < 0·001 respectively). After ileoanal anastomosis the absorptive capability of the terminal ileum was not enhanced significantly. In the mid-jejunum, the absorption of bile acids, chloride and glucose was enhanced (all P < 0·05) only after terminal ileal transposition. Terminal ileal transposition improves the absorptive capability of the terminal ileum and the mid-jejunum compared with conventional ileoanal anastomosis in this model.

Publisher

Oxford University Press (OUP)

Subject

Surgery

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