Rapid Access to Functionalized 2‐Quinolinones and Coumarins by Direct Coupling of 2‐Alkynyl‐anilines/phenols and Diazo Ketones-Reference-Cited by-同舟云学术

Rapid Access to Functionalized 2‐Quinolinones and Coumarins by Direct Coupling of 2‐Alkynyl‐anilines/phenols and Diazo Ketones

Published:2023-09-11 Issue:34 Volume:8 Page:
ISSN:2365-6549
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language:en
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Author:

Yang Meixiong¹,Zu Liansuo²,Zhao Yaqiu³,Huang Luqi³,Chen Lu⁴^ORCID

Affiliation:

1. College of Pharmacy Nanjing University of Chinese Medicine Nanjing 210023 China

2. School of Pharmaceutical Sciences Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education) Tsinghua University Beijing 100084 China

3. State Key Laboratory Breeding Base of Dao-di Herbs National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China

4. College of Plant Protection Key Laboratory of Biopesticide and Chemical Biology (Ministry of Education) Fujian Agriculture and Forestry University Fuzhou Fujian 350002 China

Abstract

AbstractThe microwave‐assisted direct coupling of 2‐alkynyl‐anilines/phenols and diazo ketones through Wolff rearrangement, intramolecular 1,4‐addition and nucleophile assisted fragmentation to synthesize functionalized 2‐quinolinones and coumarins are reported. This one‐pot manipulation features a short reaction time, high synthetic efficiency and broad substrate scope.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry

Reference20 articles.

1. See selected recent reviews and references therein:

2. The structural use of carbostyril in physiologically active substances

3. Coumarin heterocyclic derivatives: chemical synthesis and biological activity

4. Recent advances and perspectives in the synthesis of bioactive coumarins

5. For selected most recent synthesis of 2-quinolinones see: