Affiliation:
1. Department of Chemical Engineering Zhengzhou University Kexue Road Zhengzhou 450001 China
2. Institute of Clinical Pharmacology Zhengzhou University Kexue Road Zhengzhou 450001 China
3. College of Chemistry and Chemical Engineering Henan Polytechnic University Jiaozuo 454000 China
Abstract
Abstract4‐methyl‐3‐oxo‐n‐phenyl‐pentanamide, as a crucial component of atorvastatin calcium, often generates a large amount of by‐products in conventional synthesis. Here, we first developed a continuous microflow system for the continuous flow synthesis of 4‐methyl‐3‐oxo‐n‐phenyl‐pentanamide. Compared to traditional batch reactors, the reaction time was reduced by 1/12 in the microreactor. Using this device, the kinetic parameters of the reaction were determined, and a reaction kinetics model was established to investigate the effects of channel geometry and material inlet velocity on the entire reaction system. Furthermore, we studied the subsequent reactions and successfully established a fully continuous synthesis device, where the two‐step continuous flow chemical reactions were achieved at 40 minutes and a total yield of 32 %.