Study of Radiotherapy Properties and Antimicrobial Activity of Glyconanoparticles (GNPs) Generated from Imidazolium Salts

Abstract

AbstractCarbohydrate‐based imidazolium salts (IMSs) are structural patterns for the synthesis of pharmaceutically and biologically active substances. For this purpose, the chiral furanoside‐based imidazolium salt conjugated with a cysteamine (Cyt) linker attached gold and silver nanoparticles were prepared in this study. The biological applications of the HeLa and A549 cell lines using MTT cell proliferation method were exhibited to determine the biological evaluation of NPs conjugated with sugar based imidazolium salt. The satisfactory results obtained demonstrated that the synthesized glyconanoconjugates were radiotherapeutic agents. Moreover, this modification type within a galactose derived imidazolium salt is the first work in bioapplications, especially in radiotherapy. The antimicrobial activity of IMSs and their nanoconjugates against test pathogens was also evaluated using the disc diffusion technique.