Application of eco‐friendly disposable pencil graphite sensor for electrochemical evaluation and determination of podophyllotoxin using in cancer treatment

Abstract

AbstractA sensitive, simple and selective voltammetric method was developed for the quantification of plant‐derived podophyllotoxin, which is included in antineoplastic drugs, using a disposable pencil graphite electrode. Using the square‐wave voltammetry technique, podophyllotoxin gave a very good voltammetric response at +1.24 V (vs. Ag/AgCl) potential (at 0.0 V and after 60 s pre‐concentration) in Britton Robinson (pH 4.0) media. This procedure was used to detection the compound in the concentration range of 12.4–299.5 nM with a limit of detection to 2.62 nM (1.08 μg L−1). The proposed method has been successfully applied to human urine samples.