Direct C−H Alkylation of Naphthoquinone with Acetone and 1,3‐Dicarbonyl Compounds via Radical Cross Dehydrogenation Coupling

Author:

Ou Jiankang1,Liu Haoyu1,Fang Zeguo1,Zhang Qian1,Li Dong1ORCID

Affiliation:

1. New Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base School of Materials and Chemical Engineering Hubei University of Technology Wuhan 430068 China

Abstract

AbstractA direct C−H alkylation of naphthoquinones with acetone and 1,3‐dicarbonyl compounds was developed to construct C−C bonds of alkyl‐substituted naphthoquinone derivatives. It proceeded through an oxidative radical cross dehydrogenation coupling process under simple and mild conditions. This method provides a facile and efficient route for synthesis of functionalized naphthoquinones from readily available feedstocks.

Publisher

Wiley

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