Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: Observations from molecular dynamics simulations
Author:
Publisher
Wiley
Subject
Molecular Biology,Biochemistry,Structural Biology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/prot.24202/fullpdf
Reference67 articles.
1. Introduction to current and future protein therapeutics: a protein engineering perspective;Carter;Exp Cell Res,2011
2. Potent antibody therapeutics by design;Carter;Nat Rev Immunol,2006
3. Antibody structure, instability, and formulation;Wang;J Pharm Sci,2007
4. Stability of protein pharmaceuticals: an update;Manning;Pharm Res,2010
5. Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions;Agrawal;J Pharm Sci,2011
Cited by 31 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Stress-dependent Flexibility of a Full-length Human Monoclonal Antibody: Insights from Molecular Dynamics to Support Biopharmaceutical Development;Journal of Pharmaceutical Sciences;2021-11
2. In Situ Monitoring of Protein Unfolding/Structural States under Cold High-Pressure Stress;Molecular Pharmaceutics;2021-10-26
3. In Silico Analysis of Therapeutic Antibody Aggregation and the Influence of Glycosylation;Glycosylation;2021-10-06
4. Effect of charged mutation on aggregation of a pentapeptide: Insights from molecular dynamics simulations;Proteins: Structure, Function, and Bioinformatics;2021-09-21
5. Exploring the sequence features determining amyloidosis in human antibody light chains;Scientific Reports;2021-07-02
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3