More than a piece of cake: Noun classifier processing in primary progressive aphasia

Author:

Tee Boon Lead123,Li‐Ying Lorinda Kwan‐Chen4,Chen Ta‐Fu5,Yan Connie TY67,Tsoh Joshua67,Chan Andrew Lung‐Tat8,Wong Adrian9,Lo Raymond Y.10,Lu Chien Jung11,Sun Yu11,Wang Pei‐Ning121314,Lee YiChen15,Chiu Ming‐Jang5,Allen Isabel Elaine16,Battistella Giovanni17,Bak Thomas H.18,Chuang Yu‐Chen12,García Adolfo M.31920,Gorno‐Tempini Maria Luisa123

Affiliation:

1. Memory and Aging Center University of California at San Francisco San Francisco California USA

2. Department of Neurology Dyslexia Center University of California, San Francisco San Francisco California USA

3. Global Brain Health Institute University of California, San Francisco San Francisco California USA

4. Department of Special Education and Counselling The Education University of Hong Kong Hong Kong Hong Kong

5. Department of Neurology National Taiwan University Hospital Taipei Taiwan R.O.C.

6. Department of Psychiatry Prince of Wales Hospital and ShaTin Hospital Hong Kong Hong Kong

7. Department of Psychiatry Faculty of Medicine The Chinese University of Hong Kong Hong Kong Hong Kong

8. Department of Medicine Queen Elizabeth Hospital Hong Kong Hong Kong

9. Division of Neurology Department of Medicine and Therapeutics Chinese University of Hong Kong Hong Kong Hong Kong

10. Department of Neurology Buddhist Tzu Chi General Hospital Hualien Taiwan

11. Department of Neurology En Chu Kong Hospital New Taipei City Taiwan R.O.C.

12. Division of General Neurology Department of Neurological Institute Taipei Veterans General Hospital Taipei Taiwan R.O.C.

13. School of Medicine National Yang Ming Chiao Tung University College of Medicine Taipei Taiwan R.O.C.

14. Brain Research Center National Yang‐Ming Chiao‐Tung University HsinChu Taiwan R.O.C.

15. Department of Neurology National Taiwan University Hospital HsinChu Taiwan R.O.C.

16. Department of Epidemiology and Biostatistics University of California, San Francisco San Francisco California USA

17. Department of Otolaryngology ‐ Head and Neck Surgery Massachusetts Eye and Ear and Harvard Medical School Boston Massachusetts USA

18. School of Philosophy, Psychology and Language Sciences (PPLS) University of Edinburgh Edinburgh UK

19. Cognitive Neuroscience Center Universidad de San Andrés Buenos Aires Argentina

20. Departamento de Lingüística y Literatura Facultad de Humanidades Universidad de Santiago de Chile Santiago Chile

Abstract

AbstractINTRODUCTIONClinical understanding of primary progressive aphasia (PPA) has been primarily derived from Indo‐European languages. Generalizing certain linguistic findings across languages is unfitting due to contrasting linguistic structures. While PPA patients showed noun classes impairments, Chinese languages lack noun classes. Instead, Chinese languages are classifier language, and how PPA patients manipulate classifiers is unknown.METHODSWe included 74 native Chinese speakers (22 controls, 52 PPA). For classifier production task, participants were asked to produce the classifiers of high‐frequency items. In a classifier recognition task, participants were asked to choose the correct classifier.RESULTSBoth semantic variant (sv) PPA and logopenic variant (lv) PPA scored significantly lower in classifier production task. In classifier recognition task, lvPPA patients outperformed svPPA patients. The classifier production scores were correlated to cortical volume over left temporal and visual association cortices.DISCUSSIONThis study highlights noun classifiers as linguistic markers to discriminate PPA syndromes in Chinese speakers.Highlights Noun classifier processing varies in the different primary progressive aphasia (PPA) variants. Specifically, semantic variant PPA (svPPA) and logopenic variant PPA (lvPPA) patients showed significantly lower ability in producing specific classifiers. Compared to lvPPA, svPPA patients were less able to choose the accurate classifiers when presented with choices. In svPPA, classifier production score was positively correlated with gray matter volume over bilateral temporal and left visual association cortices in svPPA. Conversely, classifier production performance was correlated with volumetric changes over left ventral temporal and bilateral frontal regions in lvPPA. Comparable performance of mass and count classifier were noted in Chinese PPA patients, suggesting a common cognitive process between mass and count classifiers in Chinese languages.

Funder

Global Brain Health Institute

Alzheimer's Association

University of California, San Francisco

National Institutes of Health

Publisher

Wiley

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