Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction

Author:

Tohme Samer1,Yazdani Hamza O.1,Liu Yao1,Loughran Patricia12,van der Windt Dirk J.1,Huang Hai1,Simmons Richard L.1,Shiva Sruti3,Tai Sheng4,Tsung Allan1

Affiliation:

1. Department of Surgery; University of Pittsburgh Medical Center; Pittsburgh PA

2. Center for Biologic Imaging, Department of Cell Biology; University of Pittsburgh Medical Center; Pittsburgh PA

3. Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, Center for Metabolism and Mitochondrial Medicine; University of Pittsburgh; Pittsburgh PA

4. Department of General Surgery; Second Affiliated Hospital of Harbin Medical University; Harbin Heilongjiang China

Funder

Americas Hepato-Pancreato-Biliary Association

National Cancer Institute

National Institutes of Health

Publisher

Wiley

Subject

Hepatology

Reference38 articles.

1. Epidemiology of hepatocellular carcinoma;Sherman;Oncology,2010

2. Cancer statistics, 2016;Siegel;CA Cancer J Clin,2016

3. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis;El-Serag;Gastroenterology,2007

4. Cancer-related inflammation;Mantovani;Nature,2008

5. Role of hypoxia in the hallmarks of human cancer;Ruan;J Cell Biochem,2009

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