Structural changes in eloquent cortex secondary to glioma in sensorimotor area

Author:

Guo Yuhao12ORCID,Bao Hongbo23ORCID,Wei Zhishuo4,Fang Shengyu12,Jiang Tao125ORCID,Wang Yinyan2

Affiliation:

1. Department of Molecular Neuropathology, Beijing Neurosurgical Institute Capital Medical University Beijing China

2. Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing China

3. Department of Neurosurgery Harbin Medical University Cancer Hospital Harbin China

4. Department of Neurological Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA

5. Research Unit of Accurate Diagnosis, Treatment, and Translational Medicine of Brain Tumors Chinese Academy of Medical Sciences Beijing China

Abstract

AbstractThis study aims to investigate the structural reorganization in the sensorimotor area of the brain in patients with gliomas, distinguishing between those with impaired and unimpaired strength. Using voxel‐based morphometry (VBM) and region of interest (ROI) analysis, gray matter volumes (GMV) were compared in the contralesional primary motor gyrus, primary sensory gyrus, premotor area, bilateral supplementary motor area, and medial Brodmann area 8 (BA8). The results revealed that in patients with right hemisphere gliomas, the right medial BA8 volume was significantly larger in the impaired group than in the unimpaired group, with both groups exceeding the volume in 16 healthy controls (HCs). In patients with left hemisphere gliomas, the right supplementary motor area (SMA) was more pronounced in the impaired group compared to the unimpaired group, and both groups were greater than HCs. Additionally, the volumes of the right medial BA8 in both the impaired group were greater than HCs. Contralateral expansions in the gray matter of hand‐ and trunk‐related cortices of the premotor area, precentral gyrus, and postcentral gyrus were observed compared to HCs. Furthermore, a negative correlation was found between hand Medical Research Council (MRC) score and volumes of the contralateral SMA and bilateral medial BA8. Notably, our findings reveal consistent results across both analytical approaches in identifying significant structural reorganizations within the sensorimotor cortex. These consistent findings underscore the adaptive neuroplastic responses to glioma presence, highlighting potential areas of interest for further neurosurgical planning and rehabilitation strategies.

Funder

National Natural Science Foundation of China

Beijing Natural Science Foundation

Publisher

Wiley

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