Stratifying the Presymptomatic Phase of Genetic Frontotemporal Dementia by Serum NfL and pNfH : A Longitudinal Multicentre Study

Author:

Wilke Carlo12ORCID,Reich Selina12,Swieten John C.3,Borroni Barbara4ORCID,Sanchez‐Valle Raquel5,Moreno Fermin67,Laforce Robert8ORCID,Graff Caroline910,Galimberti Daniela1112ORCID,Rowe James B.13,Masellis Mario14,Tartaglia Maria C.15,Finger Elizabeth16ORCID,Vandenberghe Rik171819,Mendonça Alexandre20,Tagliavini Fabrizio21,Santana Isabel2223,Ducharme Simon2425ORCID,Butler Chris R.2627,Gerhard Alexander2829,Levin Johannes303132,Danek Adrian30ORCID,Otto Markus3334ORCID,Frisoni Giovanni35,Ghidoni Roberta36,Sorbi Sandro3738,Bocchetta Martina39,Todd Emily39,Kuhle Jens40ORCID,Barro Christian4041,Afonso Sónia,Almeida Maria Rosario,Anderl‐Straub Sarah,Andersson Christin,Antonell Anna,Archetti Silvana,Arighi Andrea,Balasa Mircea,Barandiaran Myriam,Bargalló Nuria,Bartha Robart,Bender Benjamin,Benussi Alberto,Benussi Luisa,Bessi Valentina,Binetti Giuliano,Black Sandra,Borrego‐Ecija Sergi,Bras Jose,Bruffaerts Rose,Cañada Marta,Cantoni Valentina,Caroppo Paola,Cash David,Castelo‐Branco Miguel,Convery Rhian,Cope Thomas,Di Fede Giuseppe,Díez Alina,Duro Diana,Fenoglio Chiara,Ferrari Camilla,Ferreira Catarina B.,Fox Nick,Freedman Morris,Fumagalli Giorgio,Gabilondo Alazne,Gasparotti Roberto,Gauthier Serge,Gazzina Stefano,Giaccone Giorgio,Gorostidi Ana,Greaves Caroline,Guerreiro Rita,Heller Carolin,Hoegen Tobias,Indakoetxea Begoña,Jelic Vesna,Jiskoot Lize,Karnath Hans‐Otto,Keren Ron,Langheinrich Tobias,Leitão Maria João,Lladó Albert,Lombardi Gemma,Loosli Sandra,Maruta Carolina,Mead Simon,Meeter Lieke,Miltenberger Gabriel,Minkelen Rick,Mitchell Sara,Moore Katrina,Nacmias Benedetta,Nicholas Jennifer,Öijerstedt Linn,Olives Jaume,Ourselin Sebastien,Padovani Alessandro,Panman Jessica,Papma Janne M.,Peakman Georgia,Pievani Michela,Pijnenburg Yolande,Polito Cristina,Premi Enrico,Prioni Sara,Prix Catharina,Rademakers Rosa,Redaelli Veronica,Rittman Tim,Rogaeva Ekaterina,Rosa‐Neto Pedro,Rossi Giacomina,Rosser Martin,Santiago Beatriz,Scarpini Elio,Schönecker Sonja,Seelaar Harro,Semler Elisa,Shafei Rachelle,Shoesmith Christen,Tábuas‐Pereira Miguel,Tainta Mikel,Taipa Ricardo,Tang‐Wai David,Thomas David L.,Thompson Paul,Thonberg Hakan,Timberlake Carolyn,Tiraboschi Pietro,Van Damme Philip,Vandenbulcke Mathieu,Veldsman Michele,Verdelho Ana,Villanua Jorge,Warren Jason,Woollacott Ione,Wlasich Elisabeth,Zetterberg Henrik,Zulaica Miren,Rohrer Jonathan D.39,Synofzik Matthis12ORCID,

Affiliation:

1. Division Translational Genomics of Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and Center of Neurology University of Tübingen Tübingen Germany

2. Center for Neurodegenerative Diseases (DZNE) Tübingen Germany

3. Department of Neurology Erasmus Medical Centre Rotterdam Netherlands

4. Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences University of Brescia Brescia Italy

5. Alzheimer's disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona Barcelona Spain

6. Cognitive Disorders Unit, Department of Neurology Donostia University Hospital San Sebastian Spain

7. Neuroscience Area Biodonostia Health Research Institute San Sebastian Spain

8. Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine Université Laval Quebec City Canada

9. Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Bioclinicum Karolinska Institute Solna Sweden

10. Unit for Hereditary Dementias, Theme Aging Karolinska University Hospital Solna Sweden

11. Fondazione IRCCS Ospedale Policlinico Milan Italy

12. University of Milan, Centro Dino Ferrari Milan Italy

13. Department of Clinical Neurosciences University of Cambridge Cambridge UK

14. Sunnybrook Health Sciences Centre Sunnybrook Research Institute, University of Toronto Toronto Canada

15. Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Canada

16. Department of Clinical Neurological Sciences University of Western Ontario London Canada

17. Laboratory for Cognitive Neurology, Department of Neurosciences KU Leuven Leuven Belgium

18. Neurology Service University Hospitals Leuven Leuven Belgium

19. Leuven Brain Institute, KU Leuven Leuven Belgium

20. Faculty of Medicine University of Lisbon Lisbon Portugal

21. Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy

22. University Hospital of Coimbra (HUC), Neurology Service, Faculty of Medicine University of Coimbra Coimbra Portugal

23. Center for Neuroscience and Cell Biology, Faculty of Medicine University of Coimbra Coimbra Portugal

24. Department of Psychiatry, McGill University Health Centre McGill University Montreal Québec Canada

25. McConnell Brain Imaging Centre Montreal Neurological Institute, McGill University Montreal Québec Canada

26. Nuffield Department of Clinical Neurosciences, Medical Sciences Division University of Oxford Oxford UK

27. Department of Brain Sciences Imperial College London London UK

28. Division of Neuroscience and Experimental Psychology, Faculty of Medicine, Biology and Health University of Manchester Manchester UK

29. Departments of Geriatric Medicine and Nuclear Medicine Essen University Hospital Essen Germany

30. Neurologische Klinik Ludwig‐Maximilians‐Universität München Munich Germany

31. German Center for Neurodegenerative Diseases (DZNE) Munich Germany

32. Munich Cluster of Systems Neurology (SyNergy) Munich Germany

33. Department of Neurology University of Ulm Ulm Germany

34. Department of Neurology Martin‐Luther‐University Halle‐Wittenberg Halle (Saale) Germany

35. Instituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy

36. Molecular Markers Laboratory IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy

37. Department of Neurofarba University of Florence Florence Italy

38. IRCCS Fondazione Don Carlo Gnocchi Florence Italy

39. Department of Neurodegenerative Disease, Dementia Research Centre UCL Institute of Neurology London UK

40. Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) University Hospital Basel, University of Basel Basel Switzerland

41. Department of Neurology Brigham and Women's Hospital and Harvard Medical School Boston MA USA

Funder

Medical Research Council Canada

NIHR Cambridge Biomedical Research Centre

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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