Effects of Denosumab, Alendronate, or Denosumab Following Alendronate on Bone Turnover, Calcium Homeostasis, Bone Mass and Bone Strength in Ovariectomized Cynomolgus Monkeys-Reference-Cited by-同舟云学术

Effects of Denosumab, Alendronate, or Denosumab Following Alendronate on Bone Turnover, Calcium Homeostasis, Bone Mass and Bone Strength in Ovariectomized Cynomolgus Monkeys

Published:2015-03-25 Issue:4 Volume:30 Page:657-669
ISSN:0884-0431
Container-title:Journal of Bone and Mineral Research
language:en
Short-container-title:J Bone Miner Res

Author:

Kostenuik Paul J¹,Smith Susan Y²,Samadfam Rana²,Jolette Jacquelin²,Zhou Lei³,Ominsky Michael S¹

Affiliation:

1. Metabolic Disorders Research; Amgen Inc.; Thousand Oaks CA

2. Musculoskeletal Research; Charles River Laboratories; Preclinical Services Montreal; Quebec Canada

3. Biostatistics; Amgen Inc.; Thousand Oaks CA

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference38 articles.

1. Denosumab for prevention of fractures in postmenopausal women with osteoporosis;Cummings;N Engl J Med.,2009

2. Denosumab in men receiving androgen-deprivation therapy for prostate cancer;Smith;N Engl J Med.,2009

3. Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL;Kostenuik;J Bone Miner Res.,2009

4. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women;Bekker;J Bone Miner Res.,2004

5. Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys;Ominsky;Bone.,2011

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