The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes-Reference-Cited by-同舟云学术

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The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes

Published:2017-03-19 Issue:11 Volume:95 Page:2307-2320
ISSN:0360-4012
Container-title:Journal of Neuroscience Research
language:en
Short-container-title:Journal of Neuroscience Research

Author:

Hohnholt Michaela C.¹^ORCID,Blumrich Eva-Maria²³,Waagepetersen Helle S.¹^ORCID,Dringen Ralf²³

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Science; University of Copenhagen; Copenhagen Denmark

2. Centre for Biomolecular Interactions Bremen, Faculty 2 (Biology/Chemistry); University of Bremen; Bremen Germany

3. Centre for Environmental Research and Sustainable Technology; Bremen Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jnr.24050/fullpdf

Reference86 articles.

1. Modulation of astrocytic glucose metabolism by the antidiabetic drug metformin;Allaman;J Neurochem,2015

2. Isolation and characterization of tightly coupled mitochondria from neurons and astrocytes in primary culture;Almeida;Brain Res,1997

3. Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway;Almeida;Nat Cell Biol,2004

4. Metformin directly acts on mitochondria to alter cellular bioenergetics;Andrzejewski;Cancer Metab,2014

5. Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons;Bak;J Cereb Blood Flow Metab,2006

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