Affiliation:
1. School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine Shanghai China
2. Institute of Rehabilitation Medicine Shanghai Academy of Traditional Chinese Medicine Shanghai China
3. Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of Education Shanghai China
4. ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital Fudan University Shanghai China
5. Department of Emergency & Intensive Care Unit Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China
Abstract
AbstractObjectivesThis study aims to develop a sulcus vocalis model in the excised canine larynx and to investigate the validity of the model.MethodsType II sulcus vocalis was created by continuous intradermal suture in six excised canine larynges. We investigated the validity of the model based on phonatory (aerodynamic and acoustic) measures, laryngeal videostroboscopy (LVS), and histological examination. The aeroacoustic parameters included phonation threshold pressure (PTP), fundamental frequency (Fo), jitter %, shimmer %, and harmonics‐to‐noise ratio (HNR).ResultsIn all the experimental specimens, there were significant increases in the PTP ([6.61 ± 1.66] cm H2O, p < 0.01), the Fo ([106.48 ± 49.59] Hz, p = 0.003), the jitter ([0.76 ± 0.42]%, p = 0.007), the shimmer ([6.87 ± 2.99%, p = 0.002]), while the HNR decreased ([5.71 ± 4.68] dB, p = 0.031), compared to that of the untreated canine larynges. The estabilished model simulated the histology with type Ⅱ sulcus.ConclusionsType Ⅱ sulcus vocalis was successfully created in excised canine larynx. The aeroacoustic and LVS analysis of this model resembled the characteristics of patients with sulcus vocalis. The model could be helpful to elucidate the pathology of the phonation, and evaluate and compare the treatments for sulcus vocalis.