Fatigue in pediatric inflammatory bowel diseases: A systematic review and a single center experience-Reference-Cited by-同舟云学术

Fatigue in pediatric inflammatory bowel diseases: A systematic review and a single center experience

Published:2023-12-10 Issue: Volume: Page:
ISSN:0277-2116
Container-title:Journal of Pediatric Gastroenterology and Nutrition
language:en
Short-container-title:J. pediatr. gastroenterol. nutr.

Author:

Turner Shira T.¹,Focht Gili²,Orlanski‐Meyer Esther²,Lev‐Tzion Raffi²,Ledder Oren²,Yogev Dotan²,Assa Amit²,Shaoul Ron³,Crowely Eileen⁴,Otley Anthony⁵,Griffiths Anne M.⁶,Turner Dan²

Affiliation:

1. Department of Psychology Ben Gurion University of the Negev Beersheba Israel

2. The Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center The Hebrew University of Jerusalem Jerusalem Israel

3. Faculty of Medicine, Pediatric Gastroenterology & Nutrition Institute, Ruth Children's Hospital of Haifa Rambam Medical Center, Technion Haifa Israel

4. Schulich School of Medicine and Dentistry, Division of Pediatric Gastroenterology, Western University, Children's Hospital of Western Ontario, London Health Sciences Center, and Children's Health Research Institute Lawson Health Research Institute London Ontario Canada

5. Department of Pediatrics, IWK Health Dalhousie University Halifax Nova Scotia Canada

6. Department of Gastroenterology, Hospital for Sick Children University of Toronto Toronto Canada

Abstract

AbstractObjectivesWe aimed to review the literature on fatigue in pediatric inflammatory bowel diseases (PIBD), to explore how it is measured, and approximate its rate in an inception pediatric cohort.MethodsStudies on fatigue were systematically reviewed and selected by two authors. Next, we retrieved the two fatigue‐related questions of the IMPACT‐III questionnaire at 4 and 12 months after diagnosis from a prospectively maintained cohort of PIBD patients, each scoring 0‐100 (lower scores imply more fatigue), and 44 healthy controls.ResultsThe systematic review identified 14 studies reporting fatigue in children, of which nine had fatigue as the primary outcome and only two provided rates of fatigue. No standalone index was identified for measuring fatigue specifically for PIBD. Of 80 children included in the inception cohort, 62 (78%) scored an average of ≤75 on the two IMPACT‐III questions (approximating at least mild fatigue), 26 (33%) scored ≤50 (at least moderate fatigue) and nine (11%) scored ≤25 (severe fatigue). In comparison, only four (9%) healthy children scored at least moderate fatigue (p = 0.007). Fatigue rates at 12 months were only slightly and nonsignificantly lower. Fatigue of any severity was reported in 92% children with active disease versus 63% of those in clinical remission (p = 0.01).ConclusionLiterature reporting on fatigue in PIBD is scarce, and no PIBD‐specific tool is available to measure fatigue. In our cohort, fatigue‐related questions were frequently scored low in children with IBD, mainly among children with active disease but also during clinical remission.

Publisher

Wiley

Subject

Gastroenterology,Pediatrics, Perinatology and Child Health

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jpn3.12039

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4. Inflammatory Bowel Disease-related Behaviours [IBD-Bx] Questionnaire: Development, Validation and Prospective Associations with Fatigue

5. Physical Training and Healthy Diet Improved Bowel Symptoms, Quality of Life, and Fatigue in Children With Inflammatory Bowel Disease