Effects of hydroxyurea on F-cells in sickle cell disease and potential impact of a second fetal globin inducer

Author:

Dai Yan12,Sangerman Jose3,Nouraie Mehdi4,Faller Aidan D.3,Oneal Patricia5,Rock Angela5,Owoyemi Oluwakemi5,Niu Xiaomei5,Nekhai Sergei5,Maharaj Dashmeet3,Cui Shauiying6,Taylor Robert5,Steinberg Martin67,Perrine Susan12358

Affiliation:

1. Cancer Center, Department of Medicine; Boston University School of Medicine; Boston Massachusetts

2. Cancer Center, Department of Pharmacology and Experimental Therapeutics; Boston University School of Medicine; Boston Massachusetts

3. Hemoglobinopathy Thalassemia Research Unit; Boston University School of Medicine; Boston Massachusetts

4. Department of Medicine; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania

5. Center for Hemoglobin Research in Minorities (CHaRM); Howard University; Washington District of Columbia

6. Hematology Oncology, Department of Medicine; Boston University School of Medicine; Boston Massachusetts

7. Medicine, Pathology and Laboratory Medicine; Boston University School of Medicine; Boston Massachusetts

8. Phoenicia Biosciences; Weston Massachusetts

Funder

National Institutes of Health

Publisher

Wiley

Subject

Hematology

Reference6 articles.

1. Fetal hemoglobin in sickle cell anemia: A glass half full?;Steinberg;Blood,2014

2. The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up;Steinberg;Am J Hematol,2010

3. Targeted fetal hemoglobin induction for treatment of beta hemoglobinopathies;Perrine;Hematol Oncol Clin N Am,2014

4. Production of F-cells in sickle cell anemia: Regulation by a genetic locus or loci separate from the beta globin cluster;Boyer;Blood,1984

5. The effect of fetal hemoglobin on the survival characteristics of sickle cells;Franco;Blood,2006

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