Analysis of Variable Frequency Stimulation Sacral Neuromodulation for Different Genders: A Chinese Multicentric Prospective Clinical Study

Author:

Wang Jipeng1,Zhang Zhipeng1,Liu Xiaodong1,Wang Jiawen1,Li Yan2,Shi Benkang2,Wang Qingwei3,Wei Zhongqing4,Song Wei5,Niu Yuanjie6,Meng Lingfeng1,Zhang Yaoguang1ORCID

Affiliation:

1. Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China

2. Department of Urology Qilu Hospital of Shandong University Jinan China

3. Department of Urology The First Affiliated Hospital of Zhengzhou University Zhengzhou China

4. Department of Urology The Second Affiliated Hospital of Nanjing Medical University Nanjing China

5. Department of Urology Shandong Provincial Hospital Jinan China

6. Department of Urology Tianjin Medical University General Hospital Tianjin China

Abstract

ABSTRACTAimSacral neuromodulation (SNM) is widely recognized as the essential treatment modality for patients suffering from various lower urinary tract disorders, particularly overactive bladder (OAB). This prospective study recruited patients who underwent variable frequency SNM treatment at six Chinese medical centers, aiming to evaluate the gender‐specific effects of this intervention and provide precise guidance on its application for clinical management.MethodsThis prospective study was managed by Beijing Hospital, and six Chinese medical centers participated in this prospective research. Inclusion and exclusion criteria were established to screen patients based on the indication for SNM. During the research, all patients were required to record 72‐h voiding diaries, urgency scores, and visual analogue scale (VAS) scores to reflect their disease symptoms. Additionally, subjective questionnaire surveys such as OAB symptom score (OABSS) and quality‐of‐life (Qol) score were recorded to reflect the patients' quality of life and treatment satisfaction.ResultsIn this study, 52 patients (male patients: 25; female patients: 27) with OAB symptoms agreed to undergo variable frequency stimulation SNM therapy and finally convert to Stage II. Regarding the baseline outcomes, no significant differences were observed between the male and female groups. In terms of postoperative indicators, male patients showed a greater improvement in Qol scores compared to their female counterparts (20.06 ± 13.12 vs. 40.83 ± 26.06, p = 0.005). The results from VAS scores indicated that pain remission was more pronounced in male patients than in female patients (0.31 ± 0.87 vs. 1.67 ± 2.16, p = 0.02). Importantly, there was a statistically significant disparity in urinary urgency between males and females (male patients: 1.19 ± 1.56; female patients: 2.17 ± 1.52, p = 0.04).ConclusionsIn our study, we found that variable frequency SNM treatment yielded sex‐specific differences in therapeutic effects, with male patients having a better outcome in some metrics. This suggests that a patient's sex may influence when variable frequency SNM is used, and in the patient's follow‐up.Trial RegistrationClinicalTrials.gov identifier: ChiCTR2000036677.

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3