Epoxide Hydrolase Conformational Heterogeneity for the Resolution of Bulky Pharmacologically Relevant Epoxide Substrates-Reference-Cited by-同舟云学术

Epoxide Hydrolase Conformational Heterogeneity for the Resolution of Bulky Pharmacologically Relevant Epoxide Substrates

Published:2018-05-25 Issue:47 Volume:24 Page:12254-12258
ISSN:0947-6539
Container-title:Chemistry - A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Serrano-Hervás Eila¹^ORCID,Casadevall Guillem¹^ORCID,Garcia-Borràs Marc²^ORCID,Feixas Ferran¹^ORCID,Osuna Sílvia¹³^ORCID

Affiliation:

1. Laboratori de Bioquímica Computacional (CompBioLab); Institut de Química Computacional i Catàlisi (IQCC); Departament de Química; Universitat de Girona (UdG); Carrer Maria Aurèlia Capmany 69 17003 Girona Spain

2. Department of Chemistry and Biochemistry; University of California, Los Angeles (UCLA); 607 Charles E. Young Drive Los Angeles CA 90095 USA

3. ICREA; Pg. Lluís Companys 23 08010 Barcelona Spain

Funder

H2020 European Research Council

Secretaría de Estado de Investigación, Desarrollo e Innovación

H2020 Marie Skłodowska-Curie Actions

Generalitat de Catalunya

FP7-PEOPLE- Career Inregration Grant

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/chem.201801068/fullpdf

Reference48 articles.

1. Protein Dynamism and Evolvability

2. The role of protein dynamics in the evolution of new enzyme function

3. Conformational footprints

4. Role of Conformational Dynamics in the Evolution of Retro-Aldolase Activity

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