1. Clinical Pharmacology Department, Hospital Clínico San CarlosIdISSC Madrid Spain
2. Department of Anaesthesiology, Reanimation and Pain TreatmentHospital Clínico San Carlos Madrid Spain
3. Pharmacology and Toxicology DepartmentComplutense University of Madrid Spain
4. Department of Essential Medicines and Health Products (EMP)World Health Organization Geneva Switzerland
5. Division of Biopharmaceutics Evaluation, Bureau of Pharmaceutical Sciences, Therapeutic Products DirectorateHealth Canada Ottawa Canada
6. Division of Pharmacology and Clinical Evaluation, Department of Human Use MedicinesSpanish Agency for Medicines and Health Care Products Madrid Spain