Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair

Author:

Witjas Franca M. R.1,van den Berg Bernard M.1,van den Berg Cathelijne W.1,Engelse Marten A.1,Rabelink Ton J.1

Affiliation:

1. The Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Division of Nephrology Leiden University Medical Center, Leiden, The Netherlands

Abstract

Abstract All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ specific vascular niche that orchestrates mechano-, growth factor, and angiocrine signaling required for tissue homeostasis and organ repair. This concise review describes how this perivascular ECM functions as a signaling platform and how this knowledge can impact the field of regenerative medicine, for example, when designing artificial matrices or using decellularized scaffolds from organs. Stem Cells Translational Medicine  2019;8:375–382

Funder

Dutch Kidney Foundation

Nierstichting

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,General Medicine

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