A Randomized, Open-Label, Crossover Phase 1 Study to Evaluate the Effects of Food on the Pharmacokinetics of a Single Oral Dose of a 15-mg Tylerdipine Tablet in Healthy Chinese Male Volunteers-Reference-Cited by-同舟云学术

A Randomized, Open-Label, Crossover Phase 1 Study to Evaluate the Effects of Food on the Pharmacokinetics of a Single Oral Dose of a 15-mg Tylerdipine Tablet in Healthy Chinese Male Volunteers

Published:2018-10-10 Issue:1 Volume:8 Page:126-132
ISSN:2160-763X
Container-title:Clinical Pharmacology in Drug Development
language:en
Short-container-title:Clinical Pharmacology in Drug Development

Author:

Wang Lu¹,Xie Lijun¹,Zhou Sufeng¹,Wang Yuanyuan¹,Chen Juan¹,Zhou Yanli²,Liu Yun¹,Zhang Hongwen¹,Tao Mingxue¹,Ou Ning¹,Shao Feng¹

Affiliation:

1. Phase 1 Clinical Trial Unit; The First Affiliated Hospital of Nanjing Medical University; Nanjing Jiangsu China

2. Department of Cardiology; The First Affiliated Hospital of Nanjing Medical University; Nanjing Jiangsu China

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cpdd.622/fullpdf

Reference21 articles.

1. Discovery and development of calcium channel blockers;Godfraind;Front Pharmacol,2017

2. Heart disease and stroke statistics-2015 update: a report from the American Heart Association;Mozaffarian;Circulation,2015

3. A further contribution regarding the influence of the different constituents of the blood on the contraction of the heart;Ringer;J Physiol,1883

4. Pharmacology of 4-(2'-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (nifedipine, BAY a 1040);Vater;Arzneimittelforschung,1972

5. Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors;Burges;J Cardiovasc Pharmacol,1987