Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for peritoneal carcinomatosis in an experimental model

Abstract

Abstract Background The combination of cytoreductive surgery (CS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is the treatment of choice for selected patients with peritoneal carcinomatosis (PC) of colorectal origin. However, it remains to be proven whether the addition of HIPEC to CS is essential for the reported survival benefit. Methods Sixty WAG/Rij rats were inoculated intraperitoneally with the rat colonic carcinoma cell line CC-531. Animals were randomized into three treatment groups: CS alone, CS followed by HIPEC (mitomycin 15 mg/m2) and CS followed by HIPEC (mitomycin 35 mg/m2). Survival was the primary outcome parameter. Results The median survival of rats treated with CS alone was 43 days. Rats receiving HIPEC 15 mg/m2 and HIPEC 35 mg/m2 both had a significantly longer median survival of 75 days (P = 0·003) and 97 days (P < 0·001) respectively. Rats receiving HIPEC showed a significantly lower tumour load at autopsy compared with rats treated with CS alone. Conclusion A combination of CS and HIPEC results in longer survival than CS alone in rats with PC of colorectal origin.