Prognostic utility of neutrophil‐to‐albumin ratio in surgically treated oral squamous cell carcinoma-Reference-Cited by-同舟云学术

Prognostic utility of neutrophil‐to‐albumin ratio in surgically treated oral squamous cell carcinoma

Published:2023-09-12 Issue:11 Volume:45 Page:2839-2850
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Yu Ya‐Yun¹,Lin Yu‐Tsai²³⁴,Chuang Hui‐Ching²³^ORCID,Chien Chih‐Yen²³⁵^ORCID,Huang Tai‐Lin³⁶,Fang Fu‐Min³⁷,Tsai Yao‐Te⁸^ORCID,Lu Hui²,Tsai Ming‐Hsien²³⁴^ORCID

Affiliation:

1. Department of Education Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan

2. Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan

3. Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center Kaohsiung Chang Gung Memorial Hospital Kaohsiung Taiwan

4. Graduate Institute of Clinical Medical Sciences, College of Medicine Chang Gung University Taoyuan Taiwan

5. Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial Hospital Kaohsiung Taiwan

6. Department of Hematology and Oncology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan

7. Department of Radiation Oncology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan

8. Department of Otolaryngology Chiayi Chang Gung Memorial Hospital Puzi Taiwan

Abstract

AbstractBackgroundWe aimed to evaluate the prognostic significance of preoperative neutrophil‐to‐albumin ratio (NAR) in oral squamous cell carcinoma (OSCC).MethodsA total of 622 patients with surgically treated OSCC were enrolled. NAR was defined as the absolute neutrophil count divided by the serum albumin level in peripheral blood before the radical surgery. Cox proportional hazards model were used to discover survival outcome‐associated factors.ResultsThe optimal cut‐off of NAR to predict overall survival (OS) was determined to be 0.1. In Cox model, high NAR was identified as an independent negative prognosticator of OS, cancer‐specific survival, and recurrence‐free survival (adjusted hazard ratio: 1.503, 1.958, and 1.727, respectively; all p < 0.05). The NAR‐based nomogram accurately predicted OS (concordance index: 0.750).ConclusionOur study suggests that preoperative NAR is a convenient and effective prognostic marker for OSCC and NAR‐based nomogram can be a promising prognostic tool in clinical setting.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27511

Reference41 articles.

1. Current Insights and Progress in the Clinical Management of Head and Neck Cancer

2. Oral diseases: a global public health challenge

3. Oral cavity and lip cancer: United Kingdom National Multidisciplinary Guidelines

4. Neutrophils Promote Tumor Progression in Oral Squamous Cell Carcinoma by Regulating EMT and JAK2/STAT3 Signaling Through Chemerin

5. Neutrophils and oral squamous cell carcinoma: lessons learned and future directions