Model‐Informed Approach Supporting Drug Development and Regulatory Evaluation for Rare Diseases

Author:

Li Ruo‐Jing1,Ma Lian1,Li Fang1,Li Liang1,Bi Youwei1,Yuan Ye1,Li Yangbing1,Xu Yuan1,Zhang Xinyuan1,Liu Jiang1,Bhattaram Venkatesh Atul1,Wang Jie1,Schuck Robert1,Pacanowski Michael1,Zhu Hao1

Affiliation:

1. Office of Clinical Pharmacology Center for Drug Evaluation and Research Food and Drug Administration Silver Spring Maryland USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference52 articles.

1. U.S. Food and Drug Administration (FDA).Rare diseases: natural history studies for drug development (draft guidance for industry).https://www.fda.gov/media/122425/download. Published March 1 2019. Accessed April 15 2020.

2. Orphan drug development: the increasing role of clinical pharmacology

3. U.S. Food and Drug Administration (FDA).Rare disease cures accelerator to support innovation and quality in rare disease drug development.https://www.fda.gov/drugs/regulatory‐science‐research‐and‐education/rare‐disease‐cures‐accelerator. Published May 16 2022. Accessed May 16 2022.

4. U.S. Food and Drug Administration (FDA).Search Orphan Drug Designations and Approvals.https://www.accessdata.fda.gov/scripts/opdlisting/oopd/. Accessed March 2 2022.

5. U.S. Food and Drug Administration (FDA).CDER conversation: model informed drug development.https://www.fda.gov/drugs/news‐events‐human‐drugs/cder‐conversation‐model‐informed‐drug‐development. Accessed June 12 2018.

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