Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: A phase I, first-in-human study-Reference-Cited by-同舟云学术

Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: A phase I, first-in-human study

Published:2013-09-17 Issue:1 Volume:54 Page:14-22
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharmacology

Author:

Hua Fei¹,Comer Gail M.²,Stockert Lori²,Jin Bo¹,Nowak John³,Pleasic-Williams Susan⁴,Wunderlich David⁴,Cheng John⁴,Beebe Jean S.²

Affiliation:

1. Department of Quantitative Clinical Sciences, BioTx Clinical Research and Development; Pfizer, Inc.; Cambridge MA USA

2. BioTx Clinical Research and Development; Pfizer, Inc.; Cambridge MA USA

3. Clinical Assay Group; Pfizer, Inc.; Andover MA USA

4. Regulated Bioanalytical Group; Pfizer, Inc.; Groton MA USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jcph.158/fullpdf

Reference19 articles.

1. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function;Parrish-Novak;Nature.,2000

2. Interleukin-21: basic biology and implications for cancer and autoimmunity;Spolski;Annu Rev Immunol.,2008

3. CD1-restricted T cells and tumor immunity;Swann;Curr Top Microbiol Immunol.,2007

4. Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain;Ozaki;Proc Natl Acad Sci USA.,2000

5. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis;Jin;J Immunol.,2004

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