Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL‐induced NFAT activation and calcium signaling

Author:

Liu Chuan123,Cao Zhen24,Zhang Wen5,Tickner Jennifer4,Qiu Heng4,Wang Chao4,Chen Kai4,Wang Ziyi4,Tan Renxiang67,Dong Shiwu2ORCID,Xu Jiake4

Affiliation:

1. Department of Anatomy Third Military Medical University Chongqing China

2. Department of Biomedical Materials Science School of Biomedical Engineering, Third Military Medical University Chongqing China

3. Department of Orthopedics The Army General Hospital Beijing China

4. School of Biomedical Sciences University of Western Australia Perth Western Australia Australia

5. Department of Surgery Chinese People’s Liberation Army 66325 Hospital Beijing China

6. State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional Biomolecules, Nanjing University Nanjing China

7. State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese Medicine Nanjing China

Funder

Scientific Research and Technology Development Program of Guangxi

Arthritis Australia

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Reference51 articles.

1. Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand

2. NF-κB-Mediated Regulation of Osteoclastogenesis

3. Osteoclast differentiation and activation

4. The riboflavin requirement of animals and man and associated metabolic relations. II. Relation of requirement to the metabolism of protein and energy;Bro‐Rasmussen F.;Nutrition Abstracts and Reviews,1958

5. Riboflavin and photoproducts in MC3T3-E1 differentiation

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