Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development

Author:

Fu Guoping1,Yu Mei1,Chen Yuhong1,Zheng Yongwei1,Zhu Wen12,Newman Debra K.13,Wang Demin14,Wen Renren1

Affiliation:

1. The Blood Research Institute; BloodCenter of Wisconsin; Milwaukee WI USA

2. Interdisciplinary Program in Biomedical Science; Medical College of Wisconsin; Milwaukee WI USA

3. Department of Pharmacology and Toxicology; Medical College of Wisconsin; Milwaukee WI USA

4. Department of Microbiology and Molecular Genetics; Medical College of Wisconsin; Milwaukee WI USA

Funder

National Institutes of Health

American Cancer Society

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference59 articles.

1. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression;Godfrey;J. Immunol.,1993

2. Regulation of thymocyte differentiation: pre-TCR signals and β-selection;Michie;Semin. Immunol.,2002

3. Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR;Haks;Semin. Immunol.,1999

4. Pleiotropic changes controlled by the pre-T-cell receptor;Boehmer;Curr. Opin. Immunol.,1999

5. Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor;Aifantis;Immunol. Rev.,2006

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