Affiliation:
1. Department of Experimental Medicine and Biochemical Sciences University of Rome Tor Vergata Rome Italy
2. The First Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection Suzhou Medical College of Soochow University Suzhou Jiangsu China
3. Institute of Translational Pharmacology (IFT) National Research Council (CNR) 00133 Rome Italy
Abstract
Hyaluronic acid (HA) is a major component of the extracellular matrix, providing essential mechanical scaffolding for cells and, at the same time, mediating essential biochemical signals required for tissue homeostasis. Many solid tumors are characterized by dysregulated HA metabolism, resulting in increased HA levels in cancer tissue. HA interacts with several cell surface receptors, such as CD44 and RHAMM, thus co‐regulating important signaling pathways in cancer development and progression. In this review, we describe the enzymes controlling HA metabolism and its intracellular effectors emphasizing their impact in cancer chemotherapy resistance. We will also explore the current and future prospects of HA‐based therapy, highlighting the opportunities and challenges in the field.
Subject
Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology
Cited by
2 articles.
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