Affiliation:
1. Faculty of Science Hokkaido University Kita-10 Nishi-8 Kita-ku, Sapporo 060-0810 Japan
2. Taiyo Nippon Sanso Corp. 10 Okubo Tsukuba, Ibaraki 300-2611 Japan
Abstract
AbstractWe developed an electrocatalytic reduction of (hetero)aryl halides under mild conditions using a proton exchange membrane (PEM) reactor. This approach allows substituting the halogeno groups on the aryl rings to protons by water and electron. Taking advantage of this transformation, deuterodehalogenation of (hetero)aryl halides, which forms mono‐deuterated (hetero)aryls, was demonstrated using heavy water as a deuterium source. The current efficiency and deuterium ratio could be increased by the conditions optimized by machine‐learning method, Bayesian optimization.
Funder
Core Research for Evolutional Science and Technology
Japan Agency for Medical Research and Development
New Energy and Industrial Technology Development Organization
Subject
Electrochemistry,Catalysis