A case of complete response to avelumab plus axitinib combination therapy for metastatic clear cell renal cell carcinoma in a kidney undergoing dialysis

Author:

Shiomi Ei1ORCID,Goto Yuta2,Hisano Mizuki2ORCID,Ito Rento1,Moriwaka Makoto1,Ikarashi Daiki1ORCID,Maekawa Shigekatsu1ORCID,Kato Renpei1,Kanehira Mitsugu1ORCID,Ujiie Takashi2,Obara Wataru1ORCID

Affiliation:

1. Department of Urology Iwate Medical University Yahaba Iwate Japan

2. Department of Urology Iwate Prefectural Ofunato Hospital Ofunato Iwate Japan

Abstract

IntroductionCombination therapies of immune checkpoint and tyrosine kinase inhibitors for end‐stage kidney disease and patients on hemodialysis need careful consideration as few case reports provide suitable management decisions.Case presentationA 70‐year‐old man who had undergone hemodialysis for 6 years due to nephrosclerosis. Avelumab plus axitinib combination therapy was performed for repeated lung metastasis, and a complete response was achieved without major side effects.ConclusionA complete response was achieved after Ave plus Axi combination therapy for clear cell renal cell carcinoma in a patient undergoing dialysis. This suggests that Ave plus Axi combination therapy may be safe and effective for dialysis patients.

Publisher

Wiley

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