Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses

Author:

Liang Jingjing1,Cade Brian E.23,Wang Heming1,Chen Han4,Gleason Kevin J.23,Larkin Emma K.5,Saxena Richa2367,Lin Xihong4,Redline Susan238,Zhu Xiaofeng1

Affiliation:

1. Department of Epidemiology and Biostatistics; School of Medicine, Case Western Reserve University; Cleveland Ohio United States of America

2. Division of Sleep and Circadian Disorders; Brigham and Women's Hospital; Boston Massachusetts United States of America

3. Division of Sleep Medicine; Harvard Medical School; Boston Massachusetts United States of America

4. Department of Biostatistics; Harvard T.H. Chan School of Public Health; Boston Massachusetts United States of America

5. Department of Medicine; Division of Allergy; Pulmonary and Critical Care; Vanderbilt University Medical Center; Nashville Tennessee United States of America

6. Center for Human Genetic Research and Department of Anesthesia; Pain, and Critical Care Medicine; Massachusetts General Hospital; Boston Massachusetts United States of America

7. Program in Medical and Population Genetics; Broad Institute; Cambridge Massachusetts United States of America

8. Division of Pulmonary; Critical Care; and Sleep Medicine; Beth Israel Deaconess Medical Center; Boston Massachusetts United States of America

Funder

National Institutes of Health

National Human Genome Research Institute

National Heart, Lung, and Blood Institute

U.S. Public Health Service Resource

National Center for Research Resources

Publisher

Wiley

Subject

Genetics (clinical),Epidemiology

Reference33 articles.

1. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees;Abecasis;Nat Genet,2002

2. Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies;Aschard;Am J Hum Genet,2014

3. Epidemiology of sleep disturbances and cardiovascular consequences;Badran;Can J Cardiol,2015

4. Respiratory arousal from sleep: mechanisms and significance;Berry;Sleep,1997

5. Apnea duration and inter-apnea interval as predictors of mortality in a prospective study;Butler;Sleep,2015

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