Patient‐Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy

Author:

Mo Shaobo12,Tang Peiyuan3,Luo Wenqin12,Zhang Long124,Li Yaqi12,Hu Xiang12,Ma Xiaoji12,Chen Yikuan12,Bao Yichao12,He Xingfeng12,Fu Guoxiang5,Xu Xiaoya3,Rao Xinxin3,Li Xiaomeng3,Guan Ruoyu3,Chen Shengzhi3,Deng Yun236,Lv Tao26,Mu Peiyuan26,Zheng Qiang27,Wang Simin28,Liu Fangqi12,Li Yiwei12,Sheng Weiqi27,Huang Dan27,Hu Chen9,Gao Jianjun3,Zhang Zhen26,Cai Sanjun124,Clevers Hans10,Peng Junjie12,Hua Guoqiang46ORCID

Affiliation:

1. Department of Colorectal Surgery Fudan University Shanghai Cancer Center Fudan University Shanghai 200032 P. R. China

2. Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 P. R. China

3. Institute of Radiation Medicine Shanghai Medical College Fudan University Shanghai 200032 P. R. China

4. Cancer Institute Fudan University Shanghai Cancer Center Shanghai 200032 P. R. China

5. Research and Early Development D1Med Technology (Shanghai) Inc Shanghai 200235 P. R. China

6. Department of Radiation Oncology Fudan University Shanghai Cancer Center Fudan University Shanghai 200032 P. R. China

7. Department of Pathology Fudan University Shanghai Cancer Center Shanghai 200032 P. R. China

8. Department of Radiology Fudan University Shanghai Cancer Center Shanghai 200032 P. R. China

9. Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore MD 21218 USA

10. Hubrecht Institute KNAW and University Medical Center Utrecht P.O. Box 85500 Utrecht 3584 CT The Netherlands

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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