1. the Second Affiliated Hospital of Dalian Medical University 467 Zhongshan Road Dalian 116027 China
2. Laboratory of Molecular Modeling and Design State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Science 457 Zhongshan Road Dalian 116023 China
3. Cancer Translational Medicine Research Center The Second Hospital, Dalian Medical University 467 Zhongshan Road Dalian 116027 China