Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure-Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects-Reference-Cited by-同舟云学术

Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure-Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

Published:2018-04-16 Issue:6 Volume:104 Page:1155-1164
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Palmér Robert¹,Mäenpää Jukka²,Jauhiainen Alexandra³,Larsson Bengt⁴,Mo John⁵,Russell Muir⁶,Root James⁷,Prothon Susanne¹,Chialda Ligia⁸,Forte Pablo⁸,Egelrud Torbjörn⁹,Stenvall Kristina¹⁰,Gardiner Philip¹

Affiliation:

1. Quantitative Clinical Pharmacology, Early Clinical Development, IMED Biotech Unit; AstraZeneca Gothenburg Sweden

2. Patient Safety, Respiratory, Inflammation, Autoimmunity, Infections and Vaccines Therapeutic Area; AstraZeneca Gothenburg Sweden

3. Early Clinical Biometrics, Early Clinical Development, IMED Biotech Unit; AstraZeneca Gothenburg Sweden

4. RIA Translational Medicines Unit, Early Clinical Development, IMED Biotech Unit; AstraZeneca Gothenburg Sweden

5. Translational Biology, Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit; AstraZeneca Gothenburg Sweden

6. Precision Medicine Laboratories, Precision Medicine and Genomics, IMED Biotech Unit; AstraZeneca Cambridge UK

7. Bioscience, Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit; AstraZeneca Gothenburg Sweden

8. Parexel Early Phase Clinical Unit; Harrow London UK

9. Umeå University; Umeå Sweden

10. Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit; AstraZeneca Gothenburg Sweden

Funder

AstraZeneca

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cpt.1053/fullpdf

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4. Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases;Korkmaz;Pharmacol. Rev.,2010

5. Eponym: Papillon-Lefevre syndrome;Dalgic;Eur. J. Pediatr.,2011

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