Affiliation:
1. Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China
2. Swiss Tropical and Public Health Institute Basel Switzerland
3. University of Basel Basel Switzerland
4. Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China
5. Friedrich Miescher Institute for Biomedical Research Basel Switzerland
6. Department of Pathology Stanford University School of Medicine Palo Alto California USA
Abstract
AbstractWe conducted a meta‐analysis to evaluate the clinical efficacy of berberine (BBR) in treating acute ischemic stroke (AIS), explore its anti‐inflammatory effects, and assess its potential applications for AIS patients. We comprehensively searched nine databases from inception until July 1, 2022, to identify clinical trials investigating the use of BBR in treating AIS. We performed statistical analyses using RevMan5.4 software and focused on primary outcomes such as inflammatory markers as well as secondary outcomes including immune system indicators, relevant biomarkers, carotid artery atherosclerosis, and adverse reactions. Our analysis included data from 17 clinical trials involving 1670 patients with AIS. Our results revealed that BBR in combination with conventional treatment significantly reduced levels of high‐sensitivity C‐reactive protein (hs‐CRP), macrophage migration inhibitory factor (MIF), interleukin‐6 (IL‐6), complement C3, hypoxic inducible factor‐1 α (HIF‐1α), cysteine protease‐3 (Caspase‐3), the national institutes of health stroke scale (NIHSS), triglycerides (TG), low‐density lipoprotein cholesterol (LDL‐C), carotid intima‐media thickness (IMT), the number of unstable plaques, and carotid crouse score on ultrasound when compared with conventional treatment alone. Furthermore, combining BBR with conventional treatment may improve the overall effective rate. Therefore, our findings suggest that BBR can be used as an adjuvant therapy for AIS due to its ability to reduce inflammatory cytokine levels, providing a novel therapeutic option for AIS. However, larger randomized controlled trials are necessary to confirm these results.
Reference77 articles.
1. Inflammation and Stroke: An Overview
2. Current advances in ischemic stroke research and therapies
3. Ischaemic stroke
4. Effects of berberine on neurologic function, serum oxidized low density lipoprotein and matrix metalloproteinase‐9 in patients with acute ischemic stroke;Chai M. J.;Herald of Medicine,2017
5. Application of transcranial Doppler ultrasonography combined with carotid ultrasonography in the evaluation of vascular lesions in elderly patients with cerebral infarction;Chen Y. Y.;Chinese Journal of Gerontology,2021
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献