Affiliation:
1. Lehrstuhl Anorganische Chemie II – Katalysatordesign Sustainable Chemistry Centre Universität Bayreuth Universitätsstraße 30, NW I 95440 Bayreuth Germany
Abstract
AbstractSyntheses of important classes of (heterocyclic) compounds, the sustainable generation of hydrogen, and the use of abundantly available metals are highly desirable. We introduce here a catalytic oxazole synthesis. Our reaction is a regio selective, one‐pot reaction and starts from esters and amino alcohols. Both are abundantly and diversely available and inexpensive starting materials. Hydrogen is liberated during the reaction and a molecular earth‐abundant metal catalyst, a Mn(I) compound, mediates the reaction most effectively ‐ and more efficiently than Ir and Ru catalysts. None of the oxazole derivatives synthesized, except the screening substrate and an active ingredient of a drug (an application), have been reported in literature yet.
Funder
Deutsche Forschungsgemeinschaft
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis