PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3-Reference-Cited by-同舟云学术

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PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

Published:2018-09-30 Issue:11 Volume:7 Page:739-747
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Yoshikado Takashi¹²,Toshimoto Kota²,Maeda Kazuya³,Kusuhara Hiroyuki³,Kimoto Emi⁴,Rodrigues A. David⁴,Chiba Koji¹,Sugiyama Yuichi²

Affiliation:

1. Laboratory of Clinical Pharmacology; Yokohama University of Pharmacy; Yokohama Kanagawa Japan

2. Sugiyama Laboratory; RIKEN Innovation Center; RIKEN; Yokohama Kanagawa Japan

3. Laboratory of Molecular Pharmacokinetics; Graduate School of Pharmaceutical Sciences; The University of Tokyo; Tokyo Japan

4. Transporter Sciences Group; ADME Sciences, Medicine Design; Pfizer; Groton Connecticut USA

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Wiley

Subject

Pharmacology (medical),Modelling and Simulation

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/psp4.12348/fullpdf

Reference34 articles.

1. The UCSF-FDA TransPortal: a public drug transporter database;Morrissey;Clin. Pharmacol. Ther.,2012

2. Transporter-mediated drug-drug interactions involving OATP substrates: predictions based on in vitro inhibition studies;Yoshida;Clin. Pharmacol. Ther.,2012

3. Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1;Elsby;Clin. Pharmacol. Ther.,2012

4. Mechanistic understanding of the nonlinear pharmacokinetics and intersubject variability of simeprevir: a PBPK-guided drug development approach;Snoeys;Clin. Pharmacol. Ther.,2016

5. Endogenous probes for drug transporters: balancing vision with reality;Rodrigues;Clin. Pharmacol. Ther.,2018

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