Affiliation:
1. Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA
2. Department of Bioengineering University of Pennsylvania Philadelphia Pennsylvania USA
3. Department of Mechanical and Aerospace Engineering North Carolina State University Raleigh North Carolina USA
Abstract
AbstractPrevious work on mitochondrial distribution in axons has shown that approximately half of the presynaptic release sites do not contain mitochondria, raising the question of how the boutons that do not contain mitochondria are supplied with ATP. Here, we develop and apply a mathematical model to study this question. Specifically, we investigate whether diffusive transport of ATP is sufficient to support the exocytic functionality in synaptic boutons which lack mitochondria. Our results demonstrate that the difference in ATP concentration between a bouton containing a mitochondrion and a neighboring bouton lacking a mitochondrion is only approximately 0.4%, which is still 3.75 times larger than the ATP concentration minimally required to support synaptic vesicle release. This work therefore suggests that passive diffusion of ATP is sufficient to maintain the functionality of boutons which do not contain mitochondria.
Funder
National Institutes of Health
National Science Foundation
Subject
Applied Mathematics,Computational Theory and Mathematics,Molecular Biology,Modeling and Simulation,Biomedical Engineering,Software
Cited by
2 articles.
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