Affiliation:
1. National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China
2. Institute of Immunization Program Henan Provincial Center for Disease Control and Prevention Zhengzhou China
3. Children's Hospital of Changchun Changchun China
4. Department of Microbiology Hunan Provincial Center for Disease Control and Prevention Changsha China
5. Institute of Viral Diseases Shaanxi Provincial Center for Disease Control and Prevention of Shaanxi Province Xi'an China
6. Laboratory of Viral Diseases Qingdao Municipal Centre for Disease Control and Prevention Qingdao China
7. Institute for Immunization and Prevention, Beijing Center for Disease Control and Prevention, Beijing Academy for Preventive Medicine Beijing Institute of Tuberculosis Control Research and Prevention Beijing China
8. Department of Infectious Diseases Children's Hospital Affiliated to Chongqing Medical University Chongqing China
9. Hebei Provincial Center for Disease Control and Prevention Shijiazhuang China
Abstract
AbstractHuman adenovirus (HAdV) is a significant viral pathogen causing severe acute respiratory infections (SARIs) in children. To improve the understanding of type distribution and viral genetic characterization of HAdV in severe cases, this study enrolled 3404 pediatric SARI cases from eight provinces of China spanning 2017–2021, resulting in the acquisition of 112 HAdV strains. HAdV‐type identification, based on three target genes (penton base, hexon, and fiber), confirmed the diversity of HAdV types in SARI cases. Twelve types were identified, including species B (HAdV‐3, 7, 55), species C (HAdV‐1, 2, 6, 89, 108, P89H5F5, Px1/Ps3H1F1, Px1/Ps3H5F5), and E (HAdV‐4). Among these, HAdV‐3 exhibited the highest detection rate (44.6%), followed by HAdV‐7 (19.6%), HAdV‐1 (12.5%), and HAdV‐108 (9.8%). All HAdV‐3, 7, 55, 4 in this study belonged to dominant lineages circulating worldwide, and the sequences of the three genes demonstrated significant conservation and stability. Concerning HAdV‐C, excluding the novel type Px1/Ps3H1F1 found in this study, the other seven types were detected both in China and abroad, with HAdV‐1 and HAdV‐108 considered the two main types of HAdV‐C prevalent in China. Two recombinant strains, including P89H5F5 and Px1/Ps3H1F1, could cause SARI as a single pathogen, warranting close monitoring and investigation for potential public health implications. In conclusion, 5 years of SARI surveillance in China provided crucial insights into HAdV‐associated respiratory infections among hospitalized pediatric patients.
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