Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

Author:

Gariani Karim1,Menzies Keir J.12,Ryu Dongryeol1,Wegner Casey J.3,Wang Xu1,Ropelle Eduardo R.4,Moullan Norman1,Zhang Hongbo1,Perino Alessia5,Lemos Vera6,Kim Bohkyung3,Park Young-Ki3,Piersigilli Alessandra67,Pham Tho X.3,Yang Yue3,Ku Chai Siah3,Koo Sung I.3,Fomitchova Anna3,Cantó Carlos8,Schoonjans Kristina6,Sauve Anthony A.9,Lee Ji-Young3,Auwerx Johan1

Affiliation:

1. Laboratory of Integrative and Systems Physiology; École Polytechnique Fédérale de Lausanne; Lausanne Switzerland

2. Interdisciplinary School of Health Sciences; University of Ottawa; Ottawa Ontario Canada

3. Department of Nutritional Sciences; University of Connecticut; Storrs CT

4. Laboratory of Molecular Biology of Exercise, School of Applied Science; University of Campinas; Limeira São Paulo Brazil

5. Metabolic Signaling; École Polytechnique Fédérale de Lausanne; Lausanne Switzerland

6. School of Life Sciences; École Polytechnique Fédérale de Lausanne; Lausanne Switzerland

7. Institute of Animal Pathology; University of Bern; Bern Switzerland

8. Nestlé Institute of Health Sciences; Lausanne Switzerland

9. Weill Cornell Medical College; New York NY

Funder

Geneva University Hospital

Heart and Stroke Foundation of Canada

USDA Multi-state/Hatch

EPFL

National Institutes of Health

Krebsforschung Schweiz/SwissCancerLeague

Systems X

SNSF

Publisher

Wiley

Subject

Hepatology

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