Affiliation:
1. Department of Pharmaceutical Chemistry Ramanbhai Patel College of Pharmacy Charotar University of Science and Technology Anand Gujarat India
2. Department of Pharmaceutical Chemistry L. J. Institute of Pharmacy L J University Ahmedabad India
Abstract
AbstractThis review article offers an environmentally benign synthesis of 1,3,4‐oxadiazole derivatives, with a focus on sustainable methodologies that have minimal impact on the environment. These derivatives, known for their diverse applications, have conventionally been associated with synthesis methods that utilize hazardous reagents and produce significant waste, thereby raising environmental concerns. The green synthesis of 1,3,4‐oxadiazole derivatives employs renewable substrates, nontoxic catalysts, and mild reaction conditions, aiming to minimize the environmental impact. Innovative techniques such as catalyst‐based, catalyst‐free, electrochemical synthesis, green‐solvent‐mediated synthesis, grinding, microwave‐mediated synthesis, and photosynthesis are implemented, providing benefits in terms of scalability, cost‐effectiveness, and ease of purification. This review emphasizes the significance of sustainable methodologies in the synthesis of 1,3,4‐oxadiazole and boots for continued exploration in this research domain.