Affiliation:
1. Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China
2. Laboratory Animal Center, School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen China
Abstract
AbstractBackgroundNeuroblastoma (NB) is a heterogeneous pediatric solid tumour strongly influenced by epigenetic modifications.MethodsThis review explores the role of N6‐methyladenosine (m6A) modifications and their readers in NB progression.ResultsDysregulation of m6A readers, including YTHDF1/2, YTHDC1, IGF2BP1/2/3, HNRNPA2B1 and HNRNPC, has been associated with susceptibility and progression.ConclusionUnderstanding the crosstalk between m6A readers and NB could offer new insights into diagnosis, prognosis, and treatment strategies.