Affiliation:
1. Biotherapy Center & Cancer Center The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China
2. State Key Laboratory of Esophageal Cancer Prevention & Treatment Zhengzhou University Zhengzhou Henan China
3. Henan Key Laboratory for Tumor Immunology and Biotherapy Zhengzhou Henan China
4. School of Life Sciences Zhengzhou University Zhengzhou Henan China
Abstract
AbstractImmunosenescence, the aging of the immune system, leads to functional deficiencies, particularly in T cells, which undergo significant changes. While numerous studies have investigated age‐related T‐cell phenotypes in healthy aging, senescent T cells have also been observed in younger populations during pathological conditions like cancer. This review summarizes the recent advancements in age‐associated alterations and markers of T cells, mechanisms, and the relationship between senescent T cells and the tumor microenvironment. We also discuss potential strategies for targeting senescent T cells to prevent age‐related diseases and enhance tumor immunotherapy efficacy.
Funder
National Natural Science Foundation of China