Mild C−H Alkoxylation of Aromatic Amides Catalyzed by Salicylaldehyde‐Co(II) Complexes-Reference-Cited by-同舟云学术

Mild C−H Alkoxylation of Aromatic Amides Catalyzed by Salicylaldehyde‐Co(II) Complexes

Published:2024-08-09 Issue: Volume: Page:
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur J Org Chem

Author:

Chen Xiao‐Hong¹,Xu Yi‐Qing¹,Huang Mao‐Gui¹,Tan Yu‐Yan¹,Li Yu‐Han²,Li Jia‐Wei²,Liu Yue‐Jin¹^ORCID

Affiliation:

1. Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules. Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals. School of Chemistry and Chemical Engineering Hubei University 430062 Wuhan China

2. Institute of Medicinal Development and Application for Aquatic Disease Control, Zhoukou Key Laboratory of Small Molecule Drug Development and Application. School of Chemistry and Chemical Engineering Zhoukou Normal University 466001 Zhoukou China

Abstract

AbstractA simple and efficient salicylaldehyde‐promoted cobalt‐catalyzed protocol for the C−H alkoxylation of aromatic amides by employing primary alcohols as the coupling partner has been developed. This method utilizes a 8‐aminoquinoline moiety as the directing group and successfully achieves the ortho−C−H alkoxylation in moderate to good yields under mild conditions. This protocol features excellent functional tolerance and broad substrate scope including natural products. In addition, the directing group could be easily removed as well.

Funder

Ministry of Higher Education and Scientific Research

Publisher

Wiley

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